SOX9 GOVERNS DIFFERENTIATION STAGE-SPECIFIC GENE EXPRESSION IN GROWTH PLATE CHONDROCYTES VIA DIRECT CONCOMITANT TRANSACTIVATION AND REPRESSION.

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.

Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state.The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature chondrocytes epitomise the precise spatiotemporal cont

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